Inflammation Mediators of inflammation A group of molecules which act as mediators of inflammation and complicated biological function Origin of inflammation mediators in kidney Extrinsic Cells in kidney infiltrative neutrophil, lymphocyte, mononuclear macrophage, platelet Intrinsic cells in kidney Mesangial cells, tubular cells, endothelial cellsInflammation • Mediators of inflammation – A group of molecules which act as mediators of inflammation and complicated biological function • Origin of inflammation mediators in kidney – Extrinsic Cells in kidney • infiltrative neutrophil, lymphocyte, mononuclear macrophage , platelet – Intrinsic cells in kidney • Mesangial cells, tubular cells, endothelial cells