有机合成化学的发展趋势 1.新试剂、新反应、新方法的发现永无止境 Epibatidine的研究 ED50: 0.005 mg/kg s.c. 1.5 mg/kg i.p. isolated from skins of the Ki:(+)0.045nM (-)0.058nM, Daly, John w.etaL. L. Am. chem. Soc (1992),114(9),3475-8 Epibatidine First total synthesis of (+)and (-)-EP First patent: Corey. E.J. et aL. USA. Daly, John w. et al J. Org. Chem.(1993). Us845042(1993) 58(21),5600-2 General Introduction of epibatidine二、有机合成化学的发展趋势 1. 新试剂、新反应、新方法的发现永无止境 H N N Cl Epibatidine isolated from skins of the Ecuadoran poison frog Epipedobates tricolor Daly, John W. etal. J. Am. Chem. Soc. (1992), 114(9), 3475-8 ED50: 0.005 mg/kg s.c. 1.5 mg/kg i.p. Daly, John W. et al. Ki: (+) 0.045nM; (-) 0.058 nM, in mice, hot plate test nAChR Corey, E. J. et al. USA. J. Org. Chem. (1993), 58(21), 5600-2. First patent: US 845042(1993) First total synthesis of (+)and (-)-EP General Introduction of Epibatidine • Epibatidine 的研究