concentrations and it may be better a bsorbed in children Carbenicillin disodium (Geopen) differs from ampicillin in its greater activity against Pseudomonas aeruginosa and Bacteroides fragilis. Also it may be active against strains of Hemophilus and Proteus that are resistant to ampicillin. A special feature of carbenicillin is its high sodium content. Since 1 g of the antibiotic contains 6 m eq of sodium, large doses may cause sodium overload in renal and cardiac patients. Carbenicillin disodium (Geopen) should not be given orally, since it is not absorbed. Carbenicillin indanyl sodium (Geocillin) is available in tablets for oral administration but is not commonly used Ticarcillin disodium Ticar) closely related carbenicillin and is available for intramuscular and intravenous use. It may have somewhat greater potency against the difficult gram-negative bacilli than carbenicillin The penicillinase-resistant penicillins are very useful in the treatment of infections caused by organisms that are resistant to penicillin G, such as hospital-acquired staphylococcal infections. If the organism turns out to be susceptible to penicillin G, it is best to switch because of itsconcentrations, and it may be better absorbed in children. Carbenicillin disodium (Geopen) differs from ampicillin in its greater activity against Pseudomonas aeruginosa and Bacteroides fragilis. Also it may be active against strains of Hemophilus and Proteus that are resistant to ampicillin . A special feature of carbenicillin is its high sodium content. Since 1 g of the antibiotic contains 6 mEq of sodium, large doses may cause sodium overload in renal and cardiac patients. Carbenicillin disodium (Geopen) should not be given orally, since it is not absorbed. Carbenicillin indanyl sodium (Geocillin) is available in tablets for oral administration but is not commonly used. Ticarcillin disodium (Ticar) is closely related to carbenicillin and is available for intramuscular and intravenous use. It may have somewhat greater potency against the difficult gram-negative bacilli than carbenicillin. The penicillinase-resistant penicillins are very useful in the treatment of infections caused by organisms that are resistant to penicillin G, such as hospital-acquired staphylococcal infections. If the organism turns out to be susceptible to penicillin G, it is best to switch because of its