Pilocarpine,a cholinomimetic alkaloid Chewing pilocarpus causes salivation.It also induces sweating Action chielly muscarinic HO HC 0 CH2-'N-CH H Muscarine H C-CH2 Pilocarpine Used clinically for treating dry mouth(xerostomia)after radiation therapy of head and neck tumor;also for treatment of glaucoma. Organ effects of cholinergic agonists Eyes:contraction of ciliary muscle and smooth muscle of the iris sphincter(miosis)-aqueous humor outflow, drainage of the anterior chamber Cardiovascular:Bradycardia(possibly preceded by tachycardia),vasodilation(all vascular beds including pulmonary and coronary-M3)and hypotension, reduction of the contraction strength(atrial and ventricular cells,Ikcdiastolic depolarization,NO- inhibitable ATP),negative chronotropic effect (inhibition of adrenergic activation). Respiratory:Bronchoconstriction,mucus secretion 66 Pilocarpine, a cholinomimetic alkaloid • Chewing pilocarpus causes salivation. It also induces sweating. • Used clinically for treating dry mouth (xerostomia) after radiation therapy of head and neck tumor; also for treatment of glaucoma. Organ effects of cholinergic agonists • Eyes: contraction of ciliary muscle and smooth muscle of the iris sphincter (miosis) – aqueous humor outflow, drainage of the anterior chamber • Cardiovascular: Bradycardia (possibly preceded by tachycardia), vasodilation (all vascular beds including pulmonary and coronary – M3) and hypotension, reduction of the contraction strength (atrial and ventricular cells, IK+ , ICa2+ diastolic depolarization , NO￾inhibitable ATP), negative chronotropic effect (inhibition of adrenergic activation). • Respiratory: Bronchoconstriction, mucus secretion