962 特约综述 2002;14(5):311-23 phenotypes of CD3 gamma and CD3 delta immunodeficiencies. J Agata Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamoto Exp Med2007;204(11):2537-44. H, et al. Regulation of T cell receptor beta gene rearrangements 34 Call ME, Pyrdol J, wiedmann M, Wucherpfennig Kw. The or. and allelic exclusion by the helix-loop-helix protein, E47. Immu- ganizing principle in the formation of the T cell receptor-CD3 nity2007;,27(6):871-84 complex.Cel2002;110:967-79 21 Eyquem S, Chemin K, Fasseu M, Bories JC. The Ets-I transcrip- 35 Feng JW, Call ME, Wucherpfennig kw. The assembly of diverse tion factor is required for complete pre-T cell receptor function immune receptors is focused on a polar membrane-embedded nd allelic exclusion at the T cell receptor beta locus. Proc Nat interaction site. PLos Biol 2006: 4(5): 768-79 22 Brady BL, Steinel NC, Bassing CH. Antigen receptor allelic tetracysteine motif contributes to assembly of CD3 delta epsilon exclusion: An update and reappraisal. J Immunol 2010, 185(7) and CD3 gamma epsilon dimers with the T cell receptor. J Biol 3801-8. Chem2006;281(48):36977-84 23 Krangel MS, Carabana J, Abbarategui l, Schlimgen R, Hawwari 37 Werlen G, Hausmann B, Palmer E A motif in the alpha beta T-cell A. Enforcing order within a complex locus: Current perspectives receptor controls positive selection by modulating ERK activity on the control of v(D) recombination at the murine T-cell recep- Nature2000;406(6794)422-6. tor alpha/delta locus. Immunol Rev 2004; 200: 224-32. 38 Amett KL, Harrison SC, Wiley DC, Crystal structure of a human 24 Abarrategui l, Krangel MS, Regulation of T cell receptor-alpha CD-epsilon/delta dimer in complex with a UCHTI single-chain gene recombination by transcription. Nat Immunol 2006: 7(10) antibody fragment. Proc Natl Acad Sci USA 2004: 101(46): 16268- 1109-15 25 Abarrategui 1, Krangel MS Noncoding transcription controls 39 Kuhns MS, Davis MM. Disruption of extracellular interactions downstream promoters to regulate T-cell receptor alpha recombi- impairs T cell receptor-CD3 complex stability and signaling. Im- nation. Embo Journal 2007, 26(20): 4380-90. munity2007;26(3) 26 Matthews AGw, Kuo AJ, Ramon-Maiques S, Han SM, Cham- 40 Kuhns MS, Girvin AT, Klein LO, Chen R, Jensen KD, Newell pagne Ks, Ivanov D, et al. RAG2 PHD finger couples histone H3 EW, et al. Evidence for a functional sidedness to the alpha beta lysine 4 trimethylation with V(D)J recombination. Nature 2007; TCR. Proc Natl Acad Sci USA 2010; 107(11): 5094-9 450(7172):1106-10 41 Kuhns MS Davis MM. Garcia KC. Deconstructing the form and 27 Liu Y, Subrahmanyam R, Chakraborty T, Sen R, Desiderio S. A function of the TCR/CD3 complex Immunity 2006; 24(2): 133- plant homeodomain in Rag-2 that binds hypermethy lated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene 42 Call ME, Schnell JR, Xu CQ, Lutz RA, Chou JJ, Wucherpfennig rearrangement. Immunity 2007, 27 (4): 561-71 KW. The structure of the zeta zeta transmembrane dimer reveals 8 Hawwari A, Krangel MS Role for rearranged variable gene seg. features essential for its assembly with the T cell receptor. Cell ments in directing secondary T cell receptor alpha recombination. Proc Natl Acad Sci USA 2007: 104(3): 903-7. 43 Call ME, Wucherpfennig Kw, Chou JJ. The structural basis for 29 Huang CY, Sleckman BP, Kanagawa S Revision of T cell recep- intramembrane assembly of an activating immunoreceptor com- tor a chain genes is required for normal T lymphocyte develop plex. Nat Immunol 2010; 11(11 ): 1023-9 ment. Proc Natl Acad Sci USA 2005; 102(40): 14356-61 44 Wucherpfennig Kw, Gagnon E, Call M, Huseby ES, Call ME. 30 Wang FP, Huang CY, Kanagawa O. Rapid deletion of rear- Structural biology of the T-cell receptor: Insights into receptor ranged T cell antigen receptor (TCR)V alpha-J alpha segment assembly, ligand recognition, and initiation of signaling. Cold by secondary rearrangement in the thymus: Role of continuous Spring Harb Perspect Biol 2010, 2(4): a005140 rearrangement of TCR alpha chain gene and positive selection in 45 Garcia KC, Adams JJ, Feng D, Ely lk. The molecular basis of the T cell repertoire formation. Proc Natl Acad Sci USA 1998 TCR germline bias for MHC is surprisingly simple. Nat Immunol 95(20):11834-9 2009,10(2):143-7. 31 Dave VP, Cao Zs, Browne C, Alarcon B, FernandezMiguel G, 46 Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Lafaille J, et al. CD3 delta deficiency arrests development of the Guinter Tl, et al. Deletion of CD4 and CD8 coreceptors permits alpha beta but not the gamma delta T cell lineage. EMBO J 1997; generation of alpha beta T cells that recognize antigens indepen- dently of the MHC Immunity 2007, 27(5): 735-50 32 Hayes SM, Love PE Stoichiometry of the murine gamma deltaT 47 Marrack P, Scott-Browne JP, Dai S, Gapin L, Kappler J. Evolu- ell receptor. J Exp Med 2006, 203(1): 47-52 tionarily conserved amino acids that control TCR-MHC interac- 33 Siegers GM, Swamy M, Fernandez.Malave E, Minguet S, Rath. tion. Annu Rev Immunol 2008: 26: 171-203 mann S, Guardo AC, et al. Different composition of the human 48 Scott-Browne JP, White J, Kappler Jw, Gapin L, Marrack P. d the mouse gamma delta T cell receptor explains different Germline-encoded amino acids in the alpha beta T-cell receptor962 · 特约综述 · 2002; 14(5): 311-23. 20 Agata Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamoto H, et al. Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immu￾nity 2007; 27(6): 871-84. 21 Eyquem S, Chemin K, Fasseu M, Bories JC. The Ets-1 transcrip￾tion factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus. Proc Natl Acad Sci USA 2004; 101(44): 15712-7. 22 Brady BL, Steinel NC, Bassing CH. Antigen receptor allelic exclusion: An update and reappraisal. J Immunol 2010; 185(7): 3801-8. 23 Krangel MS, Carabana J, Abbarategui I, Schlimgen R, Hawwari A. Enforcing order within a complex locus: Current perspectives on the control of V(D)J recombination at the murine T-cell recep￾tor alpha/delta locus. Immunol Rev 2004; 200: 224-32. 24 Abarrategui I, Krangel MS. Regulation of T cell receptor-alpha gene recombination by transcription. Nat Immunol 2006; 7(10): 1109-15. 25 Abarrategui I, Krangel MS. Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombi￾nation. Embo Journal 2007; 26(20): 4380-90. 26 Matthews AGW, Kuo AJ, Ramon-Maiques S, Han SM, Cham￾pagne KS, Ivanov D, et al. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature 2007; 450(7172): 1106-10. 27 Liu Y, Subrahmanyam R, Chakraborty T, Sen R, Desiderio S. A plant homeodomain in Rag-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Immunity 2007; 27(4): 561-71. 28 Hawwari A, Krangel MS. Role for rearranged variable gene seg￾ments in directing secondary T cell receptor alpha recombination. Proc Natl Acad Sci USA 2007; 104(3): 903-7. 29 Huang CY, Sleckman BP, Kanagawa S. Revision of T cell recep￾tor a chain genes is required for normal T lymphocyte develop￾ment. Proc Natl Acad Sci USA 2005; 102(40): 14356-61. 30 Wang FP, Huang CY, Kanagawa O. Rapid deletion of rear￾ranged T cell antigen receptor (TCR) V alpha-J alpha segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation. Proc Natl Acad Sci USA 1998; 95(20): 11834-9. 31 Dave VP, Cao ZS, Browne C, Alarcon B, FernandezMiguel G, Lafaille J, et al. CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage. EMBO J 1997; 16(6): 1360-70. 32 Hayes SM, Love PE. Stoichiometry of the murine gamma delta T cell receptor. J Exp Med 2006; 203(1): 47-52. 33 Siegers GM, Swamy M, Fernández-Malavé E, Minguet S, Rath￾mann S, Guardo AC, et al. Different composition of the human and the mouse gamma delta T cell receptor explains different phenotypes of CD3 gamma and CD3 delta immunodeficiencies. J Exp Med 2007; 204(11): 2537-44. 34 Call ME, Pyrdol J, Wiedmann M, Wucherpfennig KW. The or￾ganizing principle in the formation of the T cell receptor-CD3 complex. Cell 2002; 111(7): 967-79. 35 Feng JW, Call ME, Wucherpfennig KW. The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. PLoS Biol 2006; 4(5): 768-79. 36 Xu CQ, Call ME, Wucherpfennig KW. A membrane-proximal tetracysteine motif contributes to assembly of CD3 delta epsilon and CD3 gamma epsilon dimers with the T cell receptor. J Biol Chem 2006; 281(48): 36977-84. 37 Werlen G, Hausmann B, Palmer E. A motif in the alpha beta T-cell receptor controls positive selection by modulating ERK activity. Nature 2000; 406(6794): 422-6. 38 Arnett KL, Harrison SC, Wiley DC. Crystal structure of a human CD-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. Proc Natl Acad Sci USA 2004; 101(46): 16268- 73. 39 Kuhns MS, Davis MM. Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling. Im￾munity 2007; 26(3): 357-69. 40 Kuhns MS, Girvin AT, Klein LO, Chen R, Jensen KD, Newell EW, et al. Evidence for a functional sidedness to the alpha beta TCR. Proc Natl Acad Sci USA 2010; 107(11): 5094-9. 41 Kuhns MS, Davis MM, Garcia KC. Deconstructing the form and function of the TCR/CD3 complex. Immunity 2006; 24(2): 133- 9. 42 Call ME, Schnell JR, Xu CQ, Lutz RA, Chou JJ, Wucherpfennig KW. The structure of the zeta zeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell 2006; 127(2): 355-68. 43 Call ME, Wucherpfennig KW, Chou JJ. The structural basis for intramembrane assembly of an activating immunoreceptor com￾plex. Nat Immunol 2010; 11(11): 1023-9. 44 Wucherpfennig KW, Gagnon E, Call MJ, Huseby ES, Call ME. Structural biology of the T-cell receptor: Insights into receptor assembly, ligand recognition, and initiation of signaling. Cold Spring Harb Perspect Biol 2010; 2(4): a005140. 45 Garcia KC, Adams JJ, Feng D, Ely LK. The molecular basis of TCR germline bias for MHC is surprisingly simple. Nat Immunol 2009; 10(2): 143-7. 46 Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Guinter TI, et al. Deletion of CD4 and CD8 coreceptors permits generation of alpha beta T cells that recognize antigens indepen￾dently of the MHC. Immunity 2007; 27(5): 735-50. 47 Marrack P, Scott-Browne JP, Dai S, Gapin L, Kappler JW. Evolu￾tionarily conserved amino acids that control TCR-MHC interac￾tion. Annu Rev Immunol 2008; 26: 171-203. 48 Scott-Browne JP, White J, Kappler JW, Gapin L, Marrack P. Germline-encoded amino acids in the alpha beta T-cell receptor