ROSETTA scoring function p(sequence structure)=p(aa, aa,,aa,X) P(aa; aa, X c1,C2,…a X)≈∏Pa|) P(aa, XP(aa X) p(sequence structure) Pm P IP(aa, jE) E: reflects extent of burial P(aa,aa,,,r1) Dau is i P(aa Ei P(aa ei, rROSETTA scoring function P( sequence | structure) = P (aa1,aa 2 ,...aa | X) n P (aai ,aaj | X ) i< ∏ j P ( sequence | structure) ≈ Penv Ppair ∏ i P (aa1,aa 2 ,...aa | X ) ≈ P (aai | X ) n P (aai | X ) P (aa j | X ) Penv ∏ i = P (aai | Ei ) E reflects extent i of burial P (aai , aaj | Ei ,Ej ,rij ) P (aai | Ei ,rij ) P (aa j | Ej ,rij ) i< ∏ j Ppair =