8.3 The Hsp70 family is ubiquitous rpE ATP ATP→ ADP EtADP DnaJ DnaK 甲■ ycle is repeated Figure 8.6 Dnaj assists the binding of Dnak(hsp70), which assists the folding of nascent proteins. ATP hydrolysis drives conformational change. Grpe displaces the ADP this causes the chaperones to be released. Multiple cycles of association and dissociation may occur during the folding of a substrate protein 消当Figure 8.6 DnaJ assists the binding of DnaK (Hsp70), which assists the folding of nascent proteins. ATP hydrolysis drives conformational change. GrpE displaces the ADP; this causes the chaperones to be released. Multiple cycles of association and dissociation may occur during the folding of a substrate protein. 8.3 The Hsp70 family is ubiquitous