e denutrition: iron, copper, inc, folic acid Vit B12 hyperoxide dismutase microcirculation disturbance lip nail, apex linguae systemic factor: ulceration of stomach、 hepatitis, colonitis、 diarrhoea NEXT• denutrition ：iron, copper, zinc, folic acid, Vit B12 • hyperoxide dismutase • microcirculation disturbance ：lip, nail, apex linguae • systemic factor ：ulceration of stomach、hepatitis、colonitis、diarrhoea NEXT