Histones vs nonhistone Histones are small, very basic proteins rich in lysine and arginine. The histones are the basic building blocks of chromatin structure. The nucleoids of prokaryotic cells also have proteins associated with dna, but these proteins are quite different from the histones and do not seem to form a comparable chromatin structure Nonhistone chromosomal proteins- The histones are accompanied by a much more diverse group of DNA binding proteins called nonhistone chromosomal proteins.Histones vs Nonhistone • Histones are small, very basic proteins rich in lysine and arginine. The histones are the basic building blocks of chromatin structure. The nucleoids of prokaryotic cells also have proteins associated with DNA, but these proteins are quite different from the histones and do not seem to form a comparable chromatin structure. • Nonhistone chromosomal proteins - The histones are accompanied by a much more diverse group of DNA￾binding proteins called nonhistone chromosomal proteins