+ Transition state Activation H 0 energy -OH HO K313u3 螚 周同 ⊙6 -OH Substrate H OH (ground state) 断健所需能量 O用 00⊙-6 组键放出能量 H Change in energy GLUCOSE between substrate 新键平组 旧键断裂 and product Product 净放出能量 0⊙-0 Course of the reaction (Reaction coordinate)