EBV infects EBV shed Transmission (oropharynx) Saliva) Differentiating EBV replicates Basal layer(CD21+) Persistent infection B Cell (CD21+)Lymph nodes Liver Blood EBv-infected b cells Spleen Activated T cells Polyclonal activation Atypical lymphocytes Immunoglobulin secrection Heterophile agglutinin Cytotoxicity Immunosuppression