第6卷第3期2016年41 [4]胡珉琦.改得了基因绕不过伦理.中国科学报,2015-6-05(4) [5]Jocelyn Kaiser. The gene editor CRISPR wont fully fix sick people anytime soon. HereswhyScienceMay.3,2016.http://www.sciencemag.org/news/2016/05/ gene-editor-crispr-won-t-fully-fix-sick-people-anytime-soon-here-s-why [6]Liang P, Xu Y, Zhang X, et al. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein & Cell. 2015, 6(5):363-372 [7]Slaymaker I M, Gao L, Zetsche B, et al. Rationally engineered Cas9 nucleases with improved specificity. Science, 2015, 351, 6268 [8]Erika Check Hayden. Should you edit your children's genes? Nature,2016,Febru- ary,530,402-405.http://www.naturecom/news/should-your-edit-your-children- s- genes-1.19432 [9]Julian Savulescu, Chris Gyngel, Tom Douglas. The Ethics of Gene Editing.2015.ht tp: //petrieflom. law. harvard. edu/assets/publications/ Savulescu Gene Editing DRAFT. pdf. [1o]Regalado A. Engineering the Perfect Baby. Mit Technology Review, 2015, 5: 27 3.https://www.technologyreview.com/s/5 [1l]David Baltimore, Paul Berg,et al. a prudent path forward for genomic engin and germline gene modification, Science, 2015, 03: 26-28 [12]R. Isasi E. Kleiderman and B. M. Knoppers, Editing policy to fit the genome? Sci- ence,2016,22:337-339.http://science.sciencemag.org/content/351/6271/337 The Ethical Debate on the Research of Gene-editing of Human Embryos LI Jian-jun WANG Tian College of Humanities and Development Studies, China Agricultural University) Abstract: The first research that used new generation technology to modify human embryos aroused broad ethical debate in China and abroad, which mostly focused on safety concerns, right conflict and social justice involving gene editing in human embryos. In face of great temptation of in- terests, researchers are called to hold scientific integrity baseline and do responsible research and novation Key words: gene editing technology human embryos, ethical debate, responsible research and in novation (责任编辑肖利)*%+胡珉琦>改得了基因绕不过伦理>中国科学报$"#!$[:[#$!%#> *$+^6BGAKET+H,GC>1XG5GEGGWHD6C&'()*' P6EgD]IAAK]Hb,HB@VG6VAG+EKDHJG,66E> <GCGg,PXK>)BHGEBG$N+K>;$"#!:>XDDV.&&PPP>,BHGEBGJ+5>6C5&EGP,&"#!:&#$& 5GEGOGWHD6COBCH,VCOP6EODO]IAAKO]HbO,HB@OVG6VAGO+EKDHJGO,66EOXGCGO,OPXK *:+3H+E5*$ZI Q$.X+E5 Z$GD+A>&'()*'&&+,-OJGWH+DGW5GEGGWHDHE5HEXIJ+E DCHVC6EIBAG+CUK56DG,>*C6DGHEe &GAA$"#!$$:!$#.;:;[;L"> *L+)A+KJ+@GC(N$?+63$.GD,BXG7$GD+A>'+DH6E+AAKGE5HEGGCGW&+,-EIBAG+,G,PHDX HJVC6SGW,VGBH]HBHDK>)BHGEBG$"#!$$;$!$:":8> *8+4CH@+&XGB@<+KWGE>)X6IAWK6IGWHDK6ICBXHAWCGEg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cIE R20?1H+E !&6AAG5G6]<IJ+EHDHG,+EW9GSGA6VJGED)DIWHG,$&XHE+25CHBIADIC+AaEHSGC,HDK# *='0,&/0.1XG]HC,DCG,G+CBXDX+DI,GWEGP5GEGC+DH6EDGBXE6A65KD6J6WH]KXIJ+EGJFCK6,+C6I,GW +FC6+WGDXHB+AWGF+DGHE&XHE++EW+FC6+W$PXHBXJ6,DAK]6BI,GW6E,+]GDKB6EBGCE,$CH5XDB6E]AHBD +EW,6BH+AcI,DHBGH,,IG,HES6ASHE55GEGGWHDHE5HEXIJ+EGJFCK6,>(E]+BG6]5CG+DDGJVD+DH6E6]HEO DGCG,D,$CG,G+CBXGC,+CGB+AAGWD6X6AW,BHGEDH]HBHEDG5CHDKF+,GAHEG+EWW6CG,V6E,HFAGCG,G+CBX+EWHEO E6S+DH6E> >.<?+,5'.5GEGGWHDHE5DGBXE6A65K$XIJ+EGJFCK6,$GDXHB+AWGF+DG$CG,V6E,HFAGCG,G+CBX+EWHEO E6S+DH6E #责任编辑 肖利$ 第!卷 第"期 #$%!年 %!