CLINICAL FAETURES The usually age at onset is 35-50 years y the ratio of female to male is 3 1 Y the onset of ra is usually insidious Y Systemic symptom of fatigue, malaise, fever weight loss may be seenCLINICAL FAETURES ✓ The usually age at onset is 35-50 years ✓ The ratio of female to male is 3:1 ✓ The onset of RA is usually insidious ✓ Systemic symptom of fatigue, malaise, fever, weight loss may be seen