Experimental Systems CHAPTER 23 527 TABLE 23-2 Some inbred mouse strains commonly used in immunology Common substrains Characteristics A/He High incidence of mammary tumors in some substrains High incidence of leukemia AKR/Cum Thy 1. 2 allele in AKR/Cum, and Thy 1. 1 allele in other substrains(Thy gene encodes BALB/c BALB/cj Sensitivity to radiation BALB/C AnN Used in hybridoma technology BALB/CBy Many myeloma cell lines were generated in these mic CBA/ Gene(rd) causing retinal degeneration in CBA/ Gene (xid)causing X-linked immunodeficiency in CBA/N C3H/He Gene(rd) causing retinal degeneration C3H/He」 High incidence of mammary tumors in many substrains(these carry a C3H/HeN mammary-tumor virus that is passed via maternal milk to offspring C57BL/6J High incidence of hepatomas after irradiation C57BL/6B High complement activity C57BL/10 Very close relationship to C57BL/6 but differences in at least two loci 57BL/10ScSn Frequent partner in preparation of congenic mice C57BR 57BR/cdj High frequency of pituitary and liver tumors Very resistant to x-irradiation C57L/J usceptibility to experimental autoimmune encephalomyelitis(EAE) C57L/N High frequency of pituitary and reticular cell tumors C58 C58/ High incidence of leukemia C5B/LWN DBA1」 High incidence of mammary tumors DBA/IN DBA/ DBA/2J Low immune response to some antigens DBA/2N Low response to pneumococcal polysaccharide type Hairless(hr) gene, usually in heterozygous state immune hemolytic anemia and lupus-like nephi Autoimmune disease similar to systemic lupus erythematosus(SLE) in F, progeny from crosses with NZW NZW/N SLE-type autoimmune disease in Fi progeny from crosses with NZB High incidence of leukemia High level of aggression and severe fighting to the point of death, especially in males ndency to develop certain autoimmune diseases, most susceptible to EAE Tendency to develop several autoimmune diseases, especially EAE 129/Sy SOURCE: Adapted from Federation of American Societies for Eperimental Biology, 1979, Biological Handbooks, VoL. llL: Inbred and Genetically Defined Strains of Laboratory Animals. and adult lymph nodes are implanted into SCID mice(Fig- where they mature into T and B cells, producing a SCID ure 23-1).Because the mice lack mature T and B cells of their human mouse. Because the human lymphocytes are exposed own, they do not reject the transplanted human tissue. The to mouse antigens while they are still immature, they later implanted human fetal liver contains immature lymphocytes recognize mouse cells as self and do not mount an immuno- stem cells), which migrate to the implanted human tissues, logic response against the mouse host.and adult lymph nodes are implanted into SCID mice (Fig￾ure 23-1). Because the mice lack mature T and B cells of their own, they do not reject the transplanted human tissue. The implanted human fetal liver contains immature lymphocytes (stem cells), which migrate to the implanted human tissues, where they mature into T and B cells, producing a SCID￾human mouse. Because the human lymphocytes are exposed to mouse antigens while they are still immature, they later recognize mouse cells as self and do not mount an immuno￾logic response against the mouse host. Experimental Systems CHAPTER 23 527 TABLE 23-2 Some inbred mouse strains commonly used in immunology Strain Common substrains Characteristics A A/He High incidence of mammary tumors in some substrains A/J A/WySn AKR AKR/J High incidence of leukemia AKR/N AKR/Cum Thy 1.2 allele in AKR/Cum, and Thy 1.1 allele in other substrains (Thy gene encodes a T-cell surface protein) BALB/c BALB/cj Sensitivity to radiation BALB/c AnN Used in hybridoma technology BALB/cBy Many myeloma cell lines were generated in these mice CBA CBA/J Gene (rd) causing retinal degeneration in CBA/J CBA/H CBA/N Gene (xid) causing X-linked immunodeficiency in CBA/N C3H C3H/He Gene (rd) causing retinal degeneration C3H/HeJ High incidence of mammary tumors in many substrains (these carry a C3H/HeN mammary-tumor virus that is passed via maternal milk to offspring) C57BL/6 C57BL/6J High incidence of hepatomas after irradiation C57BL/6By High complement activity C57BL/6N C57BL/10 C57BL/10J Very close relationship to C57BL/6 but differences in at least two loci C57BL/10ScSn C57BL/10N Frequent partner in preparation of congenic mice C57BR C57BR/cdj High frequency of pituitary and liver tumors Very resistant to x-irradiation C57L C57L/J Susceptibility to experimental autoimmune encephalomyelitis (EAE) C57L/N High frequency of pituitary and reticular cell tumors C58 C58/J High incidence of leukemia C58/LwN DBA/1 DBA/1J High incidence of mammary tumors DBA/1N DBA/2 DBA/2J Low immune response to some antigens DBA/2N Low response to pneumococcal polysaccharide type III HRS HRS/J Hairless (hr) gene, usually in heterozygous state NZB NZB/BINJ High incidence of autoimmune hemolytic anemia and lupus-like nephritis NZB/N Autoimmune disease similar to systemic lupus erythematosus (SLE) in F1 progeny from crosses with NZW NZW NZW/N SLE-type autoimmune disease in F1 progeny from crosses with NZB P P/J High incidence of leukemia SJL SJL/J High level of aggression and severe fighting to the point of death, especially in males Tendency to develop certain autoimmune diseases, most susceptible to EAE SWR SWR/J Tendency to develop several autoimmune diseases, especially EAE 129 129/J High incidence of spontaneous teratocarcinoma 129/SvJ SOURCE: Adapted from Federation of American Societies for Experimental Biology, 1979, Biological Handbooks, Vol. III: Inbred and Genetically Defined Strains of Laboratory Animals