BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 G n ual delivery of VEGF and PDGF rapidly forms w图m听b( ond ton(G.ind catas statistcs significance relatve to bla laksA E dNa delivery from scaffolds Objective- in situ gene therapy Microenvironments for Stem Cells Application Focus: Engineering Vasculatu References Yannas, I V Tissue and Organ Regeneration in Adults(Springer, New York, 2001) 2. Langer, R.& Vacanti, J. P. Tissue engineering Science 260, 920-6(1993) Griffith, L G& Naughton, G. Tissue engineering--current challenges and expanding opportunities. Science 295 1009-14(2002) Richardson, T. P, Peters, M. C, Ennett, A.B.& Mooney, D. J. Polymeric system for dual growth factor deliver Nat Biotechnol 19, 1029-34(2001) Lecture 6- Biodegradable Polymers in Tissue Engineering 5 of 5BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 DNA delivery from scaffolds Objective – in situ gene therapy Microenvironments for Stem Cells Application Focus: Engineering Vasculature References 1. Yannas, I. V. Tissue and Organ Regeneration in Adults (Springer, New York, 2001). 2. Langer, R. & Vacanti, J. P. Tissue engineering. Science 260, 920-6 (1993). 3. Griffith, L. G. & Naughton, G. Tissue engineering--current challenges and expanding opportunities. Science 295, 1009-14 (2002). 4. Richardson, T. P., Peters, M. C., Ennett, A. B. & Mooney, D. J. Polymeric system for dual growth factor delivery. Nat Biotechnol 19, 1029-34 (2001). Lecture 6 – Biodegradable Polymers in Tissue Engineering 5 of 5