Abnormality 3. Coagulation (1) heredity: hemophilia, willabrand disease (2) aquired; liver disease、 renal failure、 VitK deficiency、DC (3) anticoagulant agents:Ⅷ、IAb、drugAbnormality 3. Coagulation： （1）heredity：hemophilia、willabrand disease （2）aquired：liver disease、renal failure、 VitK deficiency、 DIC （3）anticoagulant agents：Ⅷ、Ⅸ-Ab、drug