NE synthesis in nerve terminals and turnover 1 SYNTHESIS OF NOREPINEPHRINE Hydroxylation of tyrosine In COOH 2 UPTAKE INTO STORAGE VESICLES Norepinephrine is protected hydroxylase om degradation in ahydrobiopterin, O,) vesicle is metabolise CH2C-COOH RELEASE OF L-DOPA 3 NEUROTRANSMITTER DopamIne DOPA decarboxylase cell membrane (Pyridoxal phosphate) CH, CH NH2 5 REMOVAL OF NOREPINEPHRINE Dopamine rapidly taken into neuron · Uptake Is inhibited by Dopamine B-hydroxylase cocaine and imipramine BINDING TO (Ascorbate, O, 4 RECEPTOR Postsynaptic receptor Inactive Urn● of neurotransmitter bolites SYNAPTIC Norepinephrine 6 METABOLISM SPACE Catecholamine Biosynthetic Pathway and oxidized by mo amine oxida INTRACELLULAR RESPONSENE synthesis in nerve terminals and turnover Catecholamine Biosynthetic Pathway 4