Pharmacokinetics of drugs in mother Distribution >Increase of blood volume Drug concentration >Distribution of drugs to fetal in serum Plasma free Drug concentration protein ↓ in tissue 个 >Fatty tissue↑I Fat soluble drugs distribution 个 7Distribution Increase of blood volume Distribution of drugs to fetal Drug concentration in serum Pharmacokinetics of drugs in mother 7 Plasma free protein drugs Drug concentration in tissue Fatty tissue Fat soluble drugs distribution