BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 mercury lamps; in textiles; to inhibit crystallization in bacteriology and prepare cultures; in PCR hybridization in molecular biology; in the pharmaceutical industry as a suspending agent, encapsulating agent and tablet binder; and in veterinary applications as a plasma expander and o Percec: form hydrogels by H-bonding between water-insoluble short chains and long water-soluble end 4 cowned on moose noea epon lonic bondi o Sodium alginate (7)(Grant, Morris, FEBS Lett. 32, 195 (1973)) Crosslinked by divalent cations, forming salt bridges o Sensitive to salt concentration in physiological locations rosslinked by blending with cationic polymer o E.g. chitosan, polylysine Used extensively for gentle cell encapsulation Lecture 8 sical gels 5of12BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Lecture 8 – Physical gels 5 of 12 mercury lamps; in textiles; to inhibit crystallization in bacteriology and prepare cultures; in PCR hybridization in molecular biology; in the pharmaceutical industry as a suspending agent, encapsulating agent and tablet binder; and in veterinary applications as a plasma expander and hemostatic sponge. o Percec: form hydrogels by H-bonding between water-insoluble short chains and long water-soluble chains (Percec and Bera(6)) o Ionic bonding o Examples: o Sodium alginate(7) (Grant, Morris, FEBS Lett. 32, 195 (1973)) ƒ Crosslinked by divalent cations, forming salt bridges o Sensitive to salt concentration in physiological locations ƒ Crosslinked by blending with cationic polymer o E.g. chitosan, polylysine ƒ Used extensively for gentle cell encapsulation