8. 11.3 Salting-out of macromolecule 3.1 Salting in and salting out Adjusting ph of the solution to isoelectric point can weaken the repulsion between color idal particles, helping for pH> I.E.P. pH <I.E.P. coagulation of colloidal particles L.E. P Solubility of a globulin-type protein close to its isoelectric point(IEPAdjusting pH of the solution to isoelectric point can weaken the repulsion between colloidal particles, helping for coagulation of colloidal particles. 8.11.3 Salting-out of macromolecule 3.1 Salting in and salting out