Copper in the Liver-ATP7B Increasing levels of copper causes atP7A(an enzyme to release copper into portal vein to the Liver ATP7B binds copper to Cerluplasmin in the liver and releases it into the blood stream ATP7B also removes excess copper into bile Mutation of ATP7B in Wilson's disease impairs these functionsCopper in the Liver – ATP7B • Increasing levels of copper causes ATP7A (an enzyme) to release copper into portal vein to the Liver • ATP7B binds copper to Cerluplasmin in the liver and releases it into the blood stream • ATP7B also removes excess copper into bile • Mutation of ATP7B in Wilson’s disease impairs these functions