BCR+Ag PTK活化(Lyn,Fyn,B|k)(Lck,Fyn) lga/gβ的TAM ITAM-P Syk(ZAP-70 PIP2. PLC-Y GEFS(GRB-2) DAG IP3 Ca2# Ras, Rac(Ras) PKC calcineurin MAPK 转录因子激活,特定基因开放,细胞增殖分化转录因子激活, 特定基因开放, 细胞增殖分化 BCR+Ag PTK活化(Lyn, Fyn, Blk) (Lck, Fyn) Ig/Ig的ITAM ITAM-P Syk (ZAP-70) PIP2 PLC-  GEFs (GRB-2) DAG IP3 Ca2+ Ras, Rac (Ras) PKC calcineurin MAPK