从而完全数据的似然函数为 logf(yp) ncclogpe +ncilog(2PcPI)+ncrlog(2PCPT) nirlog(pi)+nrrlog(2pIpr)+nrrlog(pir) n! log nccmncrncn 由于完全数据不可观测，若记NcC,Nc,NcT,N,Nr,Nrr分别为各 个基因型的个数，p=(PCC,pPCI,PCT,pII,pIT,PTT,则有 1.NCC:NCI,NcTlnc,nI,nT,p~ MN (pc)2 2PCPI 2PCPT nc:1-(pI+Pr)1-(PI+PT)2'1-(PI+PT)2 2.NII,NITlnc,nI,nT:P~ (pr)2 2PCPI MN I2I(2PPI+() 3.NTrlnc:nI,nT:P~B(nr:pi) Previous Next First Last Back Forward 6l Í‚q,ºÍè logf(y|p) = nCC logp2 C + nCI log(2pC pI ) + nCT log(2pC pT ) + nII log(p 2 I ) + nIT log(2pI pT ) + nT T log(p 2 T T ) + log n! nCC !nCI !nCT !nII !nIT !nT T ! duÍ‚ÿå*ˇ, ePNCC , NCI , NCT , NII , NIT , NT T ©Oèà ნ .áÍ, p = (pCC , pCI , pCT , pII , pIT , pT T ), Kk 1. NCC , NCI , NCT |nC , nI , nT , p ∼ MN  nC , (pC ) 2 1 − (pI + pT ) 2 , 2pC pI 1 − (pI + pT ) 2 , 2pC pT 1 − (pI + pT ) 2  2. NII , NIT |nC , nI , nT , p ∼ MN  nI , (pI ) 2 2pC pI + (pT ) 2 , 2pC pI 2pC pI + (pT ) 2  3. NT T |nC , nI , nT , p ∼ B(nT , p2 T ) Previous Next First Last Back Forward 6