1 Introduction 14. Kulikowski C, Ammenwerth E, Bohne A, Ganser K, Haux R, Knaup P. Maier C, Michel A ger R, Wolff AC(2002) Medical imaging informatics and medical informatics Opportunities and constraints. Findings from the IMIA Yearbook of Medical Informatics 2002. Methods Inf Med, 41(2): 183-189 15. Kulikowski CA (1997) Medical imaging informatics: Challenges of definition and integration J Am Med Inform Assoc, 4(3): 252-253. 16. Pantazi SV, Arocha JF, Moehr JR(2004)Case-based medical informatics. BMC Med Inform Decis Mak. 4: 19 17. The Cancer Genome Atlas Research Network(2008)Comprehensive genomic char- acterization defines human glioblastoma genes and core pathways. Nature, 455(7216): 1061 1068. 18. Thrall JH (2007) Teleradiology: Part L. History and clinical applications. Radiology, 243(3):613-6171 Introduction 13 14. Kulikowski C, Ammenwerth E, Bohne A, Ganser K, Haux R, Knaup P, Maier C, Michel A, Singer R, Wolff AC (2002) Medical imaging informatics and medical informatics: Opportunities and constraints. Findings from the IMIA Yearbook of Medical Informatics 2002. Methods Inf Med, 41(2):183-189. 15. Kulikowski CA (1997) Medical imaging informatics: Challenges of definition and integration. J Am Med Inform Assoc, 4(3):252-253. 16. Pantazi SV, Arocha JF, Moehr JR (2004) Case-based medical informatics. BMC Med Inform Decis Mak, 4:19. 17. The Cancer Genome Atlas Research Network (2008) Comprehensive genomic char￾acterization defines human glioblastoma genes and core pathways. Nature, 455(7216):1061- 1068. 18. Thrall JH (2007) Teleradiology: Part I. History and clinical applications. Radiology, 243(3):613-617