The Simmons-Smith Reaction Enantioselective Variants Jason s. tedrow Evans group Friday seminar, February 13, 1998 I. Discovery and Mechanistic Insights l. Chiral auxiliaries Ill. Chiral Promoters MV. Catalytic Enantioselective Variants Leading Reference Charette, A ; Marcoux, J. Synlett 1995, 1197 Some Cyclopropane Containing Natural Products FR·900848 Yoshida, et al. J. Antibiotics. 1990. 43. 748 Barrett et al. J. Chem. Soc. Chem. Commun. 1995. 649 Meo 09B-0112/17/9912:18PMThe Simmons-Smith Reaction: Enantioselective Variants Jason S. Tedrow Evans group Friday seminar, February 13, 1998 I. Discovery and Mechanistic Insights II. Chiral Auxiliaries III. Chiral Promoters IV. Catalytic Enantioselective Variants Leading Reference Charette, A.; Marcoux, J. Synlett 1995, 1197 Some Cyclopropane Containing Natural Products O H N O HO OH H N O O FR - 900848 O O O NH O Me MeO Me O O Me MeO H Me H OH O H Cl Callipeltoside Minale, et al, J. Am. Chem. Soc. 1996, 118, 6202 Yoshida, et al. J. Antibiotics, 1990, 43, 748 Barrett, et al. J. Chem. Soc. Chem. Commun., 1995, 649 09B-01 12/17/99 12:18 PM