Medical Genetics Dynamic mutation The term 'dynamic mutation, was introduced to distinguish the unique properties of expanding unstable DNa repeat sequences from other forms of mutation The past decade has seen dynamic mutations uncovered as the molecular basis for a growing number of human genetic diseases and for all of the characterized rare chromosomal fragile sites.Medical Genetics Dynamic mutation The term ‘dynamic mutation’ was introduced to distinguish the unique properties of expanding, unstable DNA repeat sequences from other forms of mutation. The past decade has seen dynamic mutations uncovered as the molecular basis for a growing number of human genetic diseases and for all of the characterized ‘rare’ chromosomal fragile sites