BIOMATERIALS-TISSUE INTERACTIONS Effects of Biomaterials on cells In bulk form Cell attachment Cell proliferation(mitosis) Production of matrix molecules and enzymes(synthesis) Migration Contraction Release of pre-packaged reactive molecules(exocytosis In Particle(Molecular) Form Ingestion of particles(endocytosis)BIOMATERIALS BIOMATERIALS -TISSUE INTERACTIONS INTERACTIONS Effects of Biomaterials on Effects of Biomaterials on Cells • In Bulk Form In Bulk Form – Cell attachment Cell attachment – Cell proliferation ( Cell proliferation (mitosis mitosis ) – Production of matrix molecules and Production of matrix molecules and enzymes ( enzymes (synthesis synthesis ) – Migration Migration – Contraction Contraction – Release of pre Release of pre -packaged reactive packaged reactive molecules ( molecules (exocytosis exocytosis ) • In Particle (Molecular) Form In Particle (Molecular) Form – Ingestion of particles ( Ingestion of particles (endocytosis endocytosis )