Critical Influences:Drug Itself .Drug class (cytotoxic,biologic,anti-infective) Intrinsic PK,safety profile -Plasma clearance,tissue distribution -Dose-related toxicities(single-dose,cumulative) -Toxic sites .Target ·Encapsulation -Payload -Stability -Release kinetics Critical Influences:Liposome Size ·Physical aspects -Size distribution-outliers Size growth ·in suspension during/after reconstitution -Size measurement issues ·Safety issues Micro-capillary occlusion -MPS saturation Extravasation window Sterilization by filtration10