BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 Mechanisms of Hydrolysis One example, for polyesters: 9 Acid-catalyzed hydrolysis H O-H Base-catalyzed hydrolysis( saponification) ACM Example Structures, Properties, and Applications: (solid polymers, not water soluble) (SLIDE) olymer(class) Structur Current Applications Polylactide:(polyester) Resorbable sutures Poly(L-lactide)[PLLA bone fixtures oly(D, L-lactide)[PDLLA Monomer can be obtained -(cH-C-o-CH-E-O-H tissue engineering scaffolds for bone. liver, nerve from fermentation of corn DLLA -Atrix laboratories in First investigated by Carothers situ precipitation for scaffolds (DuPont) in 30s Drug delivery(various) Lecture 1-IntroductionBEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Mechanisms of Hydrolysis One example, for polyesters:9 Acid-catalyzed hydrolysis: Base-catalyzed hydrolysis (saponification): Example Structures, Properties, and Applications: (solid polymers, not water soluble) (SLIDE) Polymer (class) Structure Current Applications Polylactide: (polyester) Poly(L-lactide) [PLLA] Poly(D,L-lactide) [PDLLA] • Monomer can be obtained from fermentation of corn • First investigated by Carothers (DuPont) in 30s10 CH3 O CH3O -(CH-C-O-CH-C-O-)n • Resorbable sutures • bone fixtures • tissue engineering scaffolds for bone11, liver, nerve • PDLLA – Atrix laboratories in situ precipitation for scaffolds • Drug delivery (various) Lecture 1 – Introduction