Pathophysiology a Resulting a leftward shift in the oxyhemoglobin dissociation curve a binds to cardiac myoglobin, resulting myocardial depression and hypotension a Co binds to cytochromes c and P450 impaired oxygen utilization at the cellular levelPathophysiology ◼ Resulting a leftward shift in the oxyhemoglobin dissociation curve ◼ binds to cardiac myoglobin , resulting myocardial depression and hypotension ◼ CO binds to cytochromes c and P450, impaired oxygen utilization at the cellular level