Clincal manifestation Symptoms are more severe at night, and could be relieved after medication or spontaneously When severe acute asthma attack could not be mitigated within 24 hours by appropriate use of adrenomimetic, the patient is in the state of persistent asthma. The patient might be struggling due to dyspnea before he becomes weak and unable to cough. Blood pressure might decline, cyanosis might appear, and the patient might even die from acute respiratory failureClincal manifestation Symptoms are more severe at night, and could be relieved after medication or spontaneously. When severe acute asthma attack could not be mitigated within 24 hours by appropriate use of adrenomimetics, the patient is in the state of persistent asthma. The patient might be struggling due to dyspnea before he becomes weak and unable to cough. Blood pressure might decline , cyanosis might appear, and the patient might even die from acute respiratory failure