哺乳动物基因转译起始一致顺序 4-3-2-1+1+2+3+4 CC A CC·ATGG G 胰岛素基因 CC AA C A T GG 翻译 相对转译效率 胰岛素基因 Kozak A>G>T 顺序的突变 2.6:0.7:02 起始 C>A, G,T 3.3:15to2.0 *G>T Kozak 5:2.6 顺序 a-球蛋白基因 C A C CA G a-地中海贫血病C CCC A T G 注: Kozak顺序的组成,如在-3,-2.,-1和+4位替换常用碱基,翻译效率降低, Kozak consensus or Kozak sequence, is a sequence which occurs on eukaryotic mRNA and has the consensus(gcc)gccRccAUGG, where r is a purine (adenine or guanine)three bases upstream of the start codon(aUG), which is followed by another 'G. the kozak consensus sequence plays a major role in the initiation of the translation process.翻译 起始 Kozak 顺序 Kozak consensus or Kozak sequence, is a sequence which occurs on eukaryotic mRNA and has the consensus (gcc)gccRccAUGG, where R is a purine (adenine or guanine) three bases upstream of the start codon (AUG), which is followed by another 'G'. The Kozak consensus sequence plays a major role in the initiation of the translation process