sRNA与 MiRNA的区别 1)来源不同: miRNAs derive from genomic loci distinct from other recognized genes, whereas siRNAs often derive from mRNAS, transposons, viruses or heterochromatic dna 2)结构不同: miRNAs are processed from transcripts that can form local rNA hairpin structures, whereas siRNAs are processed from long bimolecular RNA duplexes or extended hairpins 3)加工不同: A single miRNA:mRNA* duplex is generated from each miRNA hairpin precursor molecule, whereas a multitude of sirNa duplexes are generated from each siRNA precursor molecule, leading to many different siRNAs accumulating from both strands of this extended dsRNA 4)保守性不同: miRNa sequences are nearly always conserved in related organisms, whereas endogenous siRNa sequences are rarely conserved These types of differences are the basis of practical guidelines for distinguishing and annotating newly discovered miRNAs and endogenous siRNAssiRNA与miRNA的区别 1）来源不同：miRNAs derive from genomic loci distinct from other recognized genes, whereas siRNAs often derive from mRNAs, transposons, viruses, or heterochromatic DNA 2）结构不同：miRNAs are processed from transcripts that can form local RNA hairpin structures, whereas siRNAs are processed from long bimolecular RNA duplexes or extended hairpins. 3）加工不同：A single miRNA:miRNA* duplex is generated from each miRNA hairpin precursor molecule, whereas a multitude of siRNA duplexes are generated from each siRNA precursor molecule, leading to many different siRNAs accumulating from both strands of this extended dsRNA. 4）保守性不同：miRNA sequences are nearly always conserved in related organisms, whereas endogenous siRNA sequences are rarely conserved. These types of differences are the basis of practical guidelines for distinguishing and annotating newly discovered miRNAs and endogenous siRNAs