Total Synthesis of Palytoxin Armstrong, R.W., Beau, J. M: Cheon, S H; Christ, H;kaloka,H:Ham,WH.Hawkins,LD; Jir WJ McWhorter, w.w., Jr. Mizuno, M, Nakata, M Stutz, A.E., Talamas, F.X.: Taniguchi, M: Tino J.A., Ueda, K, Uenishi, J, White, J B, Yonaga OH M.JAm. Chem. Soc., 1989, 111, 7525: Armstrong, OH JM. Fujioka, H, Ham, W.H., Hawkins, L D; Jin, H Kang, S.H., Kishi, Y, Martinelli, MJ McWhorter, w.w., Jr, Mizuno, M: Nakata, M Me Stutz, A.E., Talamas, F.X.: Taniguchi, M, Ti HO\ J.A., Ueda, K. Uenishi, J: White, J B: Yo M. ibid, 1989, 111, 7530, Suh, E.M., Kishi, Y. ibid. OH 1994,116,11205; Kishi,Y.Chem,Scr.1987,27, OH 573, Kishi,Y. Pure Appl Chem, 1989, 61, 313 HO OH Me oh Me OH OH OH OH OH OH Y Kishi OH OH OH OH HO Chris Hupp Cem852Total Synthesis of Palytoxin Total Synthesis of Palytoxin O NH2 OH O O OH OH O HO OH OH OH OH OH OH OH HO OH O Me OH OH OH O OH HO OH OH H O OH OH OH HO O O Me O N H N H HO OH OH Me OH H HO OH OH Me OH HO Me OH OH OH HO OH OH O O OH Me OH Me OH Armstrong, R.W.; Beau, J.M.; C heon, S.H.; C hrist, W.J.; F ujioka, H.; Ham, W.H.; Hawkins, L.D.; Jin, H.; Kan g, S.H.; Kishi, Y.; Martinelli, M.J.; McWhorter, W.W., Jr.; Mizuno, M.; Nakata, M.; Stutz, A.E.; Talamas, F.X.; Taniguchi, M.; Tino, J.A.; Ueda, K.; Uenishi, J.; W hite, J.B.; Yonaga, M. J.Am.Chem.Soc., 1989, 111, 7525; Armstrong, R.W.; Beau, J.M.; C heon, S.H.; C hrist, W.J.; F ujioka, H.; Ham, W.H.; Hawki ns, L.D.; Jin, H.; Kan g, S.H.; Kishi, Y.; Martinelli, M.J.; McWhorter, W.W., Jr.; Mizuno, M.; Nakata, M.; Stutz, A.E.; Talamas, F.X.; Taniguchi, M.; Tino, J.A.; Ueda, K.; Uenishi, J.; W hite, J.B.; Yonaga, M. ibid, 1989, 111, 7530; S u h, E.M.; Kishi, Y. ibid, 1994, 116, 11205; Kishi, Y. Chem,Scr. 1987, 27, 573; Kishi, Y. Pure & Appl. Chem, 1989, 61, 313. Y.Kishi Y.Kishi O NH2 OH O O OH OH O HO OH OH OH OH OH OH OH HO OH O Me OH OH OH O OH HO OH OH H O OH OH OH HO O Me O O N H N H HO OH OH Me OH H HO OH OH Me OH HO Me OH OH OH HO OH OH O O OH Me OH Me OH Chris Hupp CEM 852 Hupp CEM 852