Drug intervention-- Adrenergic transmission ↓：Stimulatory Tyrosine ⊥：Inhibitory Solid:Agonistic (Rate--limiting） TH… Metyrosine Dotted:Antagonistic Dopa-→DA ☐k… Reserpine Adrenergic antagonists Vesicle(DA-→NE) Phentolamine (a-blocker) Propranolol (B-blocker) 0 Amphetamine,tyramine, Release ephedrine Adrenergic agonists Bretylium,guanethidine (direct acting) Cocaine Isoproterenol NE Tricyclic antidepressants Albuterol (e.g.imipramine) Receptor Recapture +action by Uptake-1 Autonomic Receptor Classification: M1,M3,M5(Gq coupled) Muscarinic R (mAChR) M2,M4(Gi coupled) Cholinergic R Nicotinic R了 NM(neuromuscular,or muscle type) (nAChR) L NN(neuronal,or ganglion type) C1,02 Adrenergic R B1,β2，β3 Dopamine R D1,D2,D3,D4,D5 Other receptors(receptors for NANC transmitters, e.g.nitric oxide,vasoactive intestinal peptide,neuropeptide Y) 1010 Drug intervention -- Adrenergic transmission Tyrosine Dopa→DA Metyrosine Vesicle (DA→NE) Reserpine Release Bretylium, guanethidine Recapture by Uptake-1 Receptor + action NE Adrenergic agonists (direct acting) Isoproterenol Albuterol (Rate-limiting) Cocaine Tricyclic antidepressants (e.g. imipramine) Adrenergic antagonists Phentolamine (α-blocker) Propranolol (β-blocker) TH Amphetamine, tyramine, ephedrine ↓ : Stimulatory ⊥ : Inhibitory Solid: Agonistic Dotted: Antagonistic Autonomic Receptor Classification: Cholinergic R Adrenergic R Dopamine R Muscarinic R Nicotinic R M1, M3, M5 (Gq coupled) M2, M4 (Gi coupled) NM (neuromuscular, or muscle type) NN (neuronal, or ganglion type) β1, α1, α2 β2, β3 D1, D2, D3, D4, D5 Other receptors (receptors for NANC transmitters, e.g. nitric oxide, vasoactive intestinal peptide, neuropeptide Y) (mAChR) (nAChR)