2014-18 Acid production in the body Its in the production of approxmately 15,000 mmol of Co2 per day. Acidosis and Alkalosis ganic: lactate, metabolized by the liver and kidney the metabolism of proteins and other substances results in the generation A +H20一>RoH+08HP42-/0.2H2P4+18H The homeostatic response to acid load Chemical buffering Extracellular buffers 1. Chemical buffering by the extracellular and intracellular buffers 2. Changes in alveolar ventilation to control the 3. Alterations in renal H*excretion to regulate ne plasma HCO3- concentration. Henderson-Hasselbalch equation Henderson-Hasselbalch equation Eq.1)H++HCO3-<->H2C03<->H20+C02 Eq1)H++HCO3-<->H2C0O3<->H20+Co2 PCO2 PC02 X Eq2)[H+]=24 or by the henderson-Hasselbalch equation or by the Henderson-Hasselbalch equation (Eq. 3)pH 6.10+ log 03 PCO2 Acidosis: PCO2=1. X HCO3+82014-1-8 1 Acidosis and Alkalosis Hao Chuan-Ming Acid production in the body Carbonic acid: the metabolism of carbohydrates and fats (primarily derived from the diet) results in the production of approximately 15,000 mmol of CO2 per day. Non-carbonic acid: Organic: lactate, metabolized by the liver and kidney Inorganic: the metabolism of proteins and other substances results in the generation of noncarbonic acids (50 – 100 mEq, 1mEq/kg). Methionine —> glucose + urea + SO4(2-) + 2 H+ Arginine+ —> glucose (or CO2) + urea + H+ R-H2PO4 + H2O —> ROH + 0.8 HPO42- / 0.2 H2PO4- + 1.8 H+ The homeostatic response to acid load 1. Chemical buffering by the extracellular and intracellular buffers. 2. Changes in alveolar ventilation to control the PCO2. 3. Alterations in renal H+ excretion to regulate the plasma HCO3- concentration. Chemical buffering • Extracellular buffers • Intracelluar: bone Henderson-Hasselbalch equation (Eq. 1) H+ + HCO3- <—> H2CO3 <—> H2O + CO2 PCO2 (Eq. 2) [H+] = 24 x ———— [HCO3-] or by the Henderson-Hasselbalch equation [HCO3-] (Eq. 3) pH = 6.10 + log ——————— 0.03 PCO2 Henderson-Hasselbalch equation (Eq. 1) H+ + HCO3- <—> H2CO3 <—> H2O + CO2 PCO2 (Eq. 2) [H+] = 24 x ———— [HCO3-] or by the Henderson-Hasselbalch equation [HCO3-] (Eq. 3) pH = 6.10 + log ——————— 0.03 PCO2 Acidosis: PCO2=1.5 X HCO3 + 8