PK versus Safety Consider the following situations v Fast elimination v Rapid distribution to other non target tissues (Distribution) (Metabolism Accumulation) Morphine administration is In the United states and the associated with both analgesia and United Kingdom, paracetamol constipation toxicity is the most common The blood s ability to clot must be cause of acute liver failure carefully monitored while a person The grey syndrome has occurred takes warfarin in premature and other newborn infants receiving large doses of chloramphenicolPK versus Safety Consider the following situations：  Fast elimination  Rapid distribution to other non￾target tissues (Distribution) • Morphine administration is associated with both analgesia and constipation • The blood's ability to clot must be carefully monitored while a person takes warfarin. （Metabolism & Accumulation） • In the United States and the United Kingdom, paracetamol toxicity is the most common cause of acute liver failure. • The grey syndrome has occurred in premature and other newborn infants receiving large doses of chloramphenicol