生物工程学报 袁超等/植物DNA甲基化作用机制的研究进展 Chinese Journal of Biotechnolog http://journals.im.ac.cn/cjbcn May25,2020,36(5):838-848 Do:10.13345/cb.190373 @2020 Chin J Biotech, All rights reserved ·综述 植物DNA甲基化作用机制的研究进展 袁超1,张少伟2,牛义12,汤青林μ2,魏大勇12,王志敏12 1西南大学园艺园林学院南方山地园艺学教育部重点实验室,重庆40071 2重庆市蔬菜学重点实验室,重庆400715 袁超,张少伟,牛义,等.植物DNA甲基化作用机制的研究进展.生物工程学报,2020,36(5)838-848 Yuan C, Zhang SW, Niu Y, et al. Advances in research on the mechanism of DNA methylation in plants. Chin J Biotech, 2020 36(5):838-848 摘要:DNA甲基化是表观遗传学的一种重要修饰形式,也是一种重要的基因表达调控机制。DNA甲基化的异常 模式可导致植物生长发育异常。文中从植物DNA甲基化模式入手,对DNA甲基化在调控基因表达和维持基因组 稳定性的分子功能、DNA甲基化在植物发育、参与植物对生物和非生物胁迫的反应等方面的相关研究进行回顾和 总结,为深入了解DNA甲基化的作用机制并将DNA甲基化应用于植物新品种的培育和遗传改良研究提供一定的 参考。 关键词:DNA甲基化,分子功能,植物生长,胁迫反应 Advances in research on the mechanism of DNA methylation in plants Chao Yuan", Shaowei Zhang ", Yi Niu, Qinglin Tang, Dayong Wei, and zhimin Wang I Key Laboratory of Horticulture Science for Southern Mountainous Regions Ministry of Education, College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400715, China 2 Chongqing Key Laboratory of olericulture, Chongqing 400715, China Abstract: DNA methylation is an epigenetic modification that forms an important regulation mechanism of gene expression in organisms across kingdoms. Aberrant patterns of DNA methy lation can lead to plant developmental abnormalities. In this article, we briefly discuss DNA methy lation in plants and summarize its functions and biological roles in regulating gene expression and maintaining genomic stability, plant development, as well as plant responses to biotic and abiotic stresses. we intended to provide a concise reference for further understanding of the mechanism of dNa methylation and potential Received: August 20, 2019; Accepted: November 4, 2019 Supported by: National Natural Science Foundation of China(No. 31501756), Special Funds for Basic Scientific Research Business in Central olleges and Universities(No XDJK2018B039), Chongqing Foundation Research and Frontier Exploration Project (No cstc2019jcyj-msxmX0448) CorrespondingauthorsZhiminWang.Tel/fax:+86-23-68250452;E-mail:minzniwang555@163.com YiNiu.Tel/fax:+86-23-68250731;E-mail:Niuy2001134@163.com 国家自然科学基金(No.31501756),中央高校基本科研业务费专项(No.XDJK2018B039),重庆市基础研究与前沿探索专项面上项目 No.cstc20l9jcyj- msxmL04483)资助 网络出版时间:2019-11-27 网络出版地址:htp:/ kns cnki. net/kcms/ detail/1.1998q20191127.0958003html袁超 等/植物 DNA 甲基化作用机制的研究进展 Chinese Journal of Biotechnology http://journals.im.ac.cn/cjbcn May 25, 2020, 36(5): 838−848 DOI: 10.13345/j.cjb.190373 ©2020 Chin J Biotech, All rights reserved Received: August 20, 2019; Accepted: November 4, 2019 Supported by: National Natural Science Foundation of China (No. 31501756), Special Funds for Basic Scientific Research Business in Central Colleges and Universities (No. XDJK2018B039), Chongqing Foundation Research and Frontier Exploration Project (No. cstc2019jcyj-msxmX0448). Corresponding authors: Zhimin Wang. Tel/Fax: +86-23-68250452; E-mail: minzniwang_555@163.com Yi Niu. Tel/Fax: +86-23-68250731; E-mail: Niuy2001134@163.com 国家自然科学基金 (No. 31501756)，中央高校基本科研业务费专项 (No. XDJK2018B039)，重庆市基础研究与前沿探索专项面上项目 (No. cstc2019jcyj-msxmX0448) 资助。 网络出版时间：2019-11-27 网络出版地址：http://kns.cnki.net/kcms/detail/11.1998.q.20191127.0958.003.html 838 生物工程学报 植物 DNA 甲基化作用机制的研究进展 袁超 1,2，张少伟 1,2，牛义 1,2，汤青林 1,2，魏大勇 1,2，王志敏 1,2 1 西南大学 园艺园林学院 南方山地园艺学教育部重点实验室，重庆 400715 2 重庆市蔬菜学重点实验室，重庆 400715 袁超, 张少伟, 牛义, 等. 植物 DNA 甲基化作用机制的研究进展. 生物工程学报, 2020, 36(5): 838–848. Yuan C, Zhang SW, Niu Y, et al. Advances in research on the mechanism of DNA methylation in plants. Chin J Biotech, 2020, 36(5): 838–848. 摘 要: DNA 甲基化是表观遗传学的一种重要修饰形式，也是一种重要的基因表达调控机制。DNA 甲基化的异常 模式可导致植物生长发育异常。文中从植物 DNA 甲基化模式入手，对 DNA 甲基化在调控基因表达和维持基因组 稳定性的分子功能、DNA 甲基化在植物发育、参与植物对生物和非生物胁迫的反应等方面的相关研究进行回顾和 总结，为深入了解 DNA 甲基化的作用机制并将 DNA 甲基化应用于植物新品种的培育和遗传改良研究提供一定的 参考。 关键词: DNA 甲基化，分子功能，植物生长，胁迫反应 Advances in research on the mechanism of DNA methylation in plants Chao Yuan1,2, Shaowei Zhang1,2, Yi Niu1,2, Qinglin Tang1,2, Dayong Wei1,2, and Zhimin Wang1,2 1 Key Laboratory of Horticulture Science for Southern Mountainous Regions Ministry of Education, College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400715, China 2 Chongqing Key Laboratory of Olericulture, Chongqing 400715, China Abstract: DNA methylation is an epigenetic modification that forms an important regulation mechanism of gene expression in organisms across kingdoms. Aberrant patterns of DNA methylation can lead to plant developmental abnormalities. In this article, we briefly discuss DNA methylation in plants and summarize its functions and biological roles in regulating gene expression and maintaining genomic stability, plant development, as well as plant responses to biotic and abiotic stresses. We intended to provide a concise reference for further understanding of the mechanism of DNA methylation and potential ·综 述·