ldiotope inside Paratope ldiotope outside paratope variable Domains Anti-idiotype antibody Constan eree as an antigen Variable Domains Idiotype An idiotype consists of a set of epitopes associated with the V regions on the Ab antibody molecule.Each individual epitope is designated an idiotope.An idiotype is a set of epitopes displayed by the variable regions of a set of antibody molecules. Idiotopes can be associated with the paratope or lie outside it. Action of Anti-ldiotype Antibody B Cell Anti-idiotype Ab Activation B Cell MIgG -Anti-idiotype Ab 。Tolerance Antibodies against theldiotypes that lie within a paratope can crosslink MlgS.In so doing,they can activate the affected B cell.On the other hand,antibodies against Idiotypelying outside a paratope can interact with MIg through their Fab region and with the FC receptors on the same B Cell.In this configuration,Ab production is suppressed.The result is tolerance. Idiotype An idiotype consists of a set of epitopes associated with the V regions on the Ab antibody molecule. Each individual epitope is designated an idiotope. An idiotype is a set of epitopes displayed by the variable regions of a set of antibody molecules. Idiotopes can be associated with the paratope or lie outside it