Protein Folding z Balance between Chain entropy and Solvent Entropy z Non-covalent interactions – Steric restraints: bulky side chains – Hydrogen bonding – Interchain electrostatic interactions – Hydrophobic interactions – Disulfide bondsProtein Folding z Balance between Chain entropy and Solvent Entropy z Non-covalent interactions – Steric restraints: bulky side chains – Hydrogen bonding – Interchain electrostatic interactions – Hydrophobic interactions – Disulfide bonds