河北医科大学药学院 软骨藻草酸Domoie Acid Historical timeline of domoic acid Amnesie Stelifis Pooning ASP时a者周表中专 History of worldwide events associated with Chemical Structures of Domoic Acid and lomoic acid di gpumpioaad its Analogues 生 堂芝 y=- Transmission of Domoic Acid at Various 软骨藻草酸Domoic Acid Levels of Biotrophs s 有言作用。 天然药化教研室史清文教授河北医科大学药学院 天然药化教研室史清文教授 4 软骨藻草酸 Domoic Acid 1987年在加拿大东部的爱德华王子岛人们因误食了污染的海鲜食品贻贝 Mytilus edulis发生了一起食品中毒事件，造成153人中毒，中毒症状是腹痛、 拉痢、呕吐且同时记忆丧失, 意识障害, 重症者处于昏睡状态, 两周内3人死亡。 Amnesic Shellfish Poisoning (ASPs) 遗忘贝类中毒 Historical timeline of domoic acid COOH N H COOH HOOC H 1' 5' 6' 7' 8' The timeline shows discovery, isolation and numerous domoic acid events across the global waters in various countries. JPN: Japan, USA: United States, CAN: Canada, NZL: New Zealand, IRL: Ireland, FRA: France, PRT: Portugal, TUR: Turkey, ITA: Italy, SCO: Scotland, AUS: Australia, and MYS: Malaysia. History of worldwide events associated with domoic acid discovery, overconsumption and poisoning episodes COOH N H COOH HOOC H 1' 5' 6' 7' 8' Chemical Structures of Domoic Acid and its Analogues Transmission of Domoic Acid at Various Levels of Biotrophs Domoic acid is produced significantly by various species of the genus Pseudo-nitzschia that intoxicate marine animals and humans after overconsumption. COOH N H COOH HOOC H 1' 5' 6' 7' 8' Mechanism of domoic-acid-induced neurotoxicity in nerve cells 软骨藻酸(domoic acid) 与L-海人草酸和L-谷氨酸一样为脑神经系统 中的主要传递物质，是一种兴奋性氨基酸。该物质最初从红藻类Chondria armata中分离出来，与海人草酸一样都具有驱虫作用。 1991年美国西海岸加利福尼亚的蒙特里湾发现鹈及鹈形目的鸟类大 量死亡，从鸟吃的鳀等鱼类肉中检出软骨藻草酸180 mg/kg，内脏中检出 2300 mg/kg。 软骨藻草酸 Domoic Acid COOH N H COOH HOOC H 1' 5' 6' 7' 8