Memory B Cells Generation is associated with class switch and somatic hypermutation in the germinal centers of spleen and lymph node Germinal centers provide an environment where B cells with mutations for high affinity for Ag are clonally selected and expanded Serve as memory cells for subsequent responses Affinity maturation increases the production of high affinity Ab in the secondary responseMemory B Cells ◼ Generation is associated with class switch and somatic hypermutation in the germinal centers of spleen and lymph node ◼ Germinal centers provide an environment where B cells with mutations for high affinity for Ag are clonally selected and expanded ◼ Serve as memory cells for subsequent responses ◼ Affinity maturation increases the production of high affinity Ab in the secondary response