Histopathology of UC Begin within the rectum and extend a variable adjacent leve 25%rectum 25-50% rectum and sigmoid or descending colon One third extend adjacent to splenic flexure or involve the entire colon A few involve the terminal ileum Diffuse, continuous, superficial and not-focal inflammation Submucosa or mucosaHistopathology of UC Begin within the rectum and extend a variable adjacent level -25% rectum -25~50% rectum and sigmoid or descending colon -One third extend adjacent to splenic flexure or involve the entire colon -A few involve the terminal ileum Diffuse, continuous, superficial and not-focal inflammation Submucosa or mucosa