国必生 国生 Preparation of TDDS(patch) In vitro evaluation of TDDS Mixing drug with reservoir,matrix,or adhesive Casting into films and drying Parallel permeation cells Laminating with other structural components ·Die cutting Vertical permeation cells ·Final packaging 国生一 国上生一 In vitro evaluation of TDDS In vitro evaluation of TDDS ·Donor solution ·Skin Poorly soluble drug:saturation solution .Soluble drug:10 times higher ·Human skin Receptor solution should maintain a good sink ·Animal skin condition ·Temperature often keep at32±lC .Living skin equivalents 国坠生 Learning objectives Concept:Stratum comeum,TDDS Understand factors affecting drug permeation through the skin The difference between different type of semisolids Preparation of semisolid dosage forms ©Advantages of TDDS 88 Shanghai Jiao Tong University Preparation of TDDS (patch) • Mixing drug with reservoir, matrix, or adhesive • Casting into films and drying • Laminating with other structural components • Die cutting • Final packaging Shanghai Jiao Tong University In vitro evaluation of TDDS • Parallel permeation cells • Vertical permeation cells Shanghai Jiao Tong University In vitro evaluation of TDDS • Donor solution • Poorly soluble drug: saturation solution • Soluble drug: 10 times higher • Receptor solution should maintain a good sink condition • Temperature often keep at 32±1℃ Shanghai Jiao Tong University In vitro evaluation of TDDS • Skin •Human skin •Animal skin •Living skin equivalents Shanghai Jiao Tong University Learning objectives Concept: Stratum corneum, TDDS Understand factors affecting drug permeation through the skin The difference between different type of semisolids Preparation of semisolid dosage forms Advantages of TDDS