Some important differencesi 1 RNA is made of ribonucleotides 2. RNA polymerase catalyzes the reaction, which does not require a primer(de novo synthesis) 3. The RNA product does not remain base-paired to the template DNA strand 4. Less accurate (error rate: 10-4)7 Some important differences: 1.RNA is made of ribonucleotides 2.RNA polymerase catalyzes the reaction, which does not require a primer (de novo synthesis) 3.The RNA product does not remain base-paired to the template DNA strand 4.Less accurate (error rate: 10-4)