BEH. 462/3.962J Molecular Principles of Biomaterials Spring 2003 ③·⑧ 一￥￥ lanate Krcrptar m by FR-enpeod 助料(bmr Liposomes are electrostatically stabilized at neutral pH Change in net surface charge leads to membrane fusion within endosomes AraC cytosine-B-D-arabinofuranoside References Eniola, A O.& Hammer, D. A Artificial polymeric cells for targeted drug delivery. J Control Release 87, 15-22 2. Halin, C. et al. Enhancement of the antitumor activity of interleukin- 12 by targeted delivery to neovasculature. Nat Biotech/20,2649(2002) Pardridge, W.M. Drug and gene targeting to the brain with molecular Trojan horses. Nat Rev Drug Discov 1, 131 9(2002) 4. Wickham, T J. Ligand-directed targeting of genes to the site of disease. Nat Med 9, 135-9(2003) Shi, G, Guo, W, Stephenson, S M.& Lee, R. J. Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations. J Control Release 80 309-19(2002) Kumamoto, T et al. Induction of tumor-specific protective immunity by in situ Langerhans cell vaccine. Nat Biotechnol 20, 64-9(2002) Lecture 17-Drug targeting 7 of 7BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 ƒ Liposomes are electrostatically stabilized at neutral pH • Change in net surface charge leads to membrane fusion within endosomes • AraC = cytosine-β-D-arabinofuranoside ƒ Cytotoxic agent for anti-tumor therapy References 1. Eniola, A. O. & Hammer, D. A. Artificial polymeric cells for targeted drug delivery. J Control Release 87, 15-22 (2003). 2. Halin, C. et al. Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature. Nat Biotechnol 20, 264-9 (2002). 3. Pardridge, W. M. Drug and gene targeting to the brain with molecular Trojan horses. Nat Rev Drug Discov 1, 131­ 9 (2002). 4. Wickham, T. J. Ligand-directed targeting of genes to the site of disease. Nat Med 9, 135-9 (2003). 5. Shi, G., Guo, W., Stephenson, S. M. & Lee, R. J. Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations. J Control Release 80, 309-19 (2002). 6. Kumamoto, T. et al. Induction of tumor-specific protective immunity by in situ Langerhans cell vaccine. Nat Biotechnol 20, 64-9 (2002). Lecture 17 – Drug targeting 7 of 7