Granulation tissue showing numerous blood vessels,edema,and a loose ECM containing Trichrome stain of mature scar,showing occasional inflammatory cells.Collagen is dense collagen with only scattered vascular stained blue by the trichrome stain;minimal channels.ECM,extracellular matrix. mature collagen can be seen at this pointGranulation tissue showing numerous blood vessels, edema, and a loose ECM containing occasional inflammatory cells. Collagen is stained blue by the trichrome stain; minimal mature collagen can be seen at this point Trichrome stain of mature scar, showing dense collagen with only scattered vascular channels. ECM, extracellular matrix