OCH2 CH3 COoH BrCH, CH,CH, Br OCH2CH Diethyl malonate 丙二酸二乙酯 NaoCH, CH3 BrCH, CH,CH,Br OCH2 CH3 CH3CH,OH OCH2 CH3 Diethyl malonate 丙二酸二乙酯 OCH2CH3 NaoCH, CH3 OCH2C CH3CH2OH BrCH,Ch2CH BrCH, CH, CH oCH,c oCH2CH OCH2CH )NaOH gH heat COOH CO OCH2CH 脱羧Diethyl malonate 丙 二 酸 二 乙 酯 O O OCH2CH3 OCH2CH3 H - Na + O O OCH2CH3 OCH2CH3 H H BrCH2CH2CH2Br NaOCH2CH3 CH3CH2OH SN2 NaOCH2CH3 CH3CH2OH BrCH2CH2CH2 O O OCH2CH3 OCH2CH3 H BrCH2CH2CH2 O O OCH2CH3 OCH2CH3 - Na + SN2 COOH Diethyl malonate 丙 二 酸 二 乙 酯 O O OCH2CH3 OCH2CH3 H H + BrCH2CH2CH2Br 1) NaOH heat 2) H3O + 脱 羧 O O OH OH - CO2 O O OCH2CH3 OCH2CH3 COOH