2/10/2016 New antibiotics approved by the Industry's dilemma:new antibiotics are in demand but the US Food and Drug Administration returns are often low and take years to be realized 15 12 -s.coom 198g161978807098 andand Antibiotic Safety Future of Chemotherapeutic Agents Therapeutic index:risk Antibiotic Safety versus benefit Target virulence factors Reactions of antibiotics Sequester iron,which feeds pathogens with other drugs ·Damage to organs out of5 Antimicrobial peptides produced by ·Risk to the fetus various organisms Allergies to antibiotics ·Phage therapy Bacteriocins:antimicrobial peptides produced by bacteria ·Natural products 2/10/2016 8 Industry's dilemma: new antibiotics are in demand but the returns are often low and take years to be realized Antibiotic Safety • Therapeutic index: risk versus benefit • Reactions of antibiotics with other drugs • Damage to organs • Risk to the fetus • Allergies to antibiotics Future of Chemotherapeutic Agents • Target virulence factors • Sequester iron, which feeds pathogens • Antimicrobial peptides produced by various organisms • Phage therapy • B i i i i bi l id Bacteriocins: antimicrobial peptides produced by bacteria • Natural products