Bone marrow models x Gene libraries are used to create antibodies from the bone marrow xx Antibody production through a random concatenation from gene libraries xx Simple or complex libraries An individual genome corresponds to four libraries Library 1 Library 2 ibrary 3 Library 4 A1 A2 A3 A4 A5 A6 A7 A8 B2 B3 B6 B7 BB c1 c5]c6lc7ca D1 D2 D3 D4 D5/D6(D7 DB four 16 bit segments A3 B2 C8 D5 a 64 bit chainBone Marrow Models Gene libraries are used to create antibodies from the bone marrow Antibody production through a random concatenation from gene libraries Simple or complex libraries An individual genome corresponds to four libraries: Library 1 Library 2 Library 3 Library 4 A1 A2 A3 A4 A5 A6 A7 A8 A3 B2 C8 D5 A3 B2 C8 D5 A3 B2 C8 D5 = four 16 bit segments = a 64 bit chain Expressed Ab molecule B1 B2 B3 B4 B5 B6 B7 B8 C1 C2 C3 C4 C5 C6 C7 C8 D1 D2 D3 D4 D5 D6 D7 D8